Pesquisa sobre:
PRE-B CELL RECEPTORS
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DeCS
Descritor
Inglês
:
Pre-B Cell Receptors
Descritor
Espanhol
:
Receptores de Células Precursoras de Linfócitos B
Descritor
Português
:
Receptores de Células Precursoras de Linfócitos B
Categoria:
D12.776.124.486.485.950.750
D12.776.124.790.651.950.750
D12.776.377.715.548.950.750
D12.776.543.750.705.816.821.750
Definição
Inglês
:
Membrane
proteins
in precursor
B-LYMPHOCYTES
(pre-B Cells). They are composed of membrane-bound MU
IMMUNOGLOBULIN HEAVY CHAINS
in complex with SURROGATE
LIGHT
CHAINS instead of conventional
IMMUNOGLOBULIN LIGHT CHAINS
. Only successful rearrangement of the VDJ segments, at the Ig heavy chain gene locus (IMMUNOGLOBULIN HEAVY CHAIN GENES), will generate mu heavy chains that can pair with surrogate
light
chains. Thus formation of the
pre-B cell receptors
is an important checkpoint in the development of mature B
cells.
Nota Histórica
Inglês
:
2008
Qualificadores Permitidos
Inglês
:
administration & dosage
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
chemistry
classification
drug effects
deficiency
genetics
history
immunology
isolation & purification
metabolism
physiology
radiation effects
therapeutic use
ultrastructure
Número do Registro:
52788
Identificador Único:
D054420
Ocorrência na BVS
:
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